https://jurnal.healthsains.co.id/index.php/jhs <p><a href="https://www.healthylucascounty.org/">slot gacor</a><a href="https://theoriginallouiscafe.net/">slot777</a>Journal of Health Sains (JHS) Is a journal published by CV. Syntax Corporation Indonesia. JHS will publish scientific articles in the health sciences. The articles published are the results of research, studies or critical and comprehensive scientific studies on important and current issues or reviews of scientific books.<br /><br /></p> en-US <p>Authors who publish with this journal agree to the following terms:</p> <ul> <li>Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a<a href="https://creativecommons.org/licenses/by-sa/4.0">Creative Commons Attribution-ShareAlike 4.0 International (CC-BY-SA).</a> that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.</li> <li>Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.</li> <li>Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.</li> </ul> jurnalhealthsain@gmail.com (Jurnal Health Sains) jurnalhealthsain@gmail.com (Journal Support Assistant) Mon, 29 Jun 2026 00:00:00 +0000 OJS 3.2.1.2 http://blogs.law.harvard.edu/tech/rss 60 https://jurnal.healthsains.co.id/index.php/jhs/article/view/2856 <p>Cinnamomum burmannii (Nees &amp; T. Nees) Blume is one of the most widely traded cinnamon species globally and an increasingly investigated botanical source for metabolic, antimicrobial, anti-inflammatory, dermatological, and gastroprotective applications. Cultivated predominantly in Indonesia and distributed across tropical Southeast Asia and southern China, C. burmannii is distinguished by its high coumarin content, chemically rich and variable phytochemistry—dominated by cinnamaldehyde, A-type proanthocyanidins, D-borneol-rich essential oil, and phenolic acids—and by the emergence of standardized bioactive fractions with clinical development. This review integrates the totality of published evidence across two parallel research streams: a broad international body of phytochemical and pharmacological work from Indonesian, Chinese, Belgian, Portuguese, and other research groups, and a focused translational program from Dexa Laboratories of Biomolecular Sciences (DLBS), comprising DLBS3233—a combined C. burmannii/Lagerstroemia speciosa fraction supported by multiple Phase II–III randomized controlled trials in prediabetes, type 2 diabetes mellitus, and polycystic ovary syndrome—and DLBS2411, a bark-derived proton pump downregulator and mucoprotector with clinical trials in GERD, peptic ulcer, and functional dyspepsia. The collective evidence demonstrates robust antidiabetic activity via α-glucosidase inhibition, insulin receptor phosphorylation, PPARγ/GLUT4 upregulation, and TRPA1/GLP-1 stimulation; antioxidant and antilipidemic effects across multiple animal and human models; broad-spectrum antimicrobial activity against foodborne pathogens, Staphylococcus aureus, Aspergillus flavus, and Malassezia furfur, with characterized molecular mechanisms; anti-inflammatory action through NF-κB/IKK suppression; wound-healing promotion via M1 macrophage inhibition; and gastroprotective dual-mechanism activity.</p> Raymond R. Tjandrawinata Copyright (c) 2026 Raymond R. Tjandrawinata https://creativecommons.org/licenses/by-sa/4.0 https://jurnal.healthsains.co.id/index.php/jhs/article/view/2856 Mon, 29 Jun 2026 00:00:00 +0000