The Relationship between Platelet Count and Hematocrit with the Severity of Dengue Hemorrhagic Fever at Lendemoripa Christian Hospital – West Sumba – East Nusa Tenggara

2025-01-06T07:26:13+00:00

Dengue virus infection remains a significant public health problem in tropical and subtropical regions, including Indonesia. This study aims to evaluate the clinical severity and hematological findings among dengue patients at RSK Lende Moripa, West Sumba, NTT. This retrospective descriptive study collected medical record data of adult patients hospitalized during the study period. A total of 76 patients who met the inclusion criteria were analyzed, with data on gender, age, clinical manifestations, and hematological profiles (platelet count and hematocrit) being examined. Of the 76 patients, 45 (59%) were male, and the majority (63%) were between 18-40 years old. Clinical manifestations showed 41 cases (54%) of Dengue Hemorrhagic Fever (DHF) and 35 cases (46%) of Dengue Fever (DF). There were no cases of Dengue Shock Syndrome (DSS). Significant differences in platelet levels were found between DF and DHF cases (p=0.01), while no significant difference was observed in hematocrit levels (p=0.4). Thrombocytopenia was more severe in DHF patients. Platelet levels are critical in assessing dengue severity, with thrombocytopenia being more prevalent in DHF cases. Monitoring platelet levels is essential for early detection of severe dengue cases

EVALUATION OF THE EFFECT OF ANTIOXIDANT AGENTS OF SHRIMP - SEA JELLYFISH (Catostylus sp) bioactive peptide compounds ON MACROSCOPIC CHANGES IN THE LIVER OF WISTAR RATS (Rattus novergicus)

2025-01-24T08:37:45+00:00

Jellyfish contain bioactive compounds that have the potential to act as antioxidants. Bioactive peptides in jellyfish are still rarely studied in research, so exploration regarding the benefits of bioactive compounds in jellyfish needs to be carried out. This research aims to isolate bioactive peptides from Catostylus sp. jellyfish, determine the levels of isolated protein compounds, and evaluate the antioxidant activity of bioactive peptides through in vitro and in vivo tests. The research was carried out using the method of isolating bioactive peptides through ammonium sulfate fractionation and analyzing its activity on rat as test animals. Jellyfish sample preparations were ground and extracted to obtain crude protein, which was then fractionated using ammonium sulfate. The antioxidant activity of bioactive peptides was tested using the DPPH method. Preliminary research findings indicate that bioactive peptides from jellyfish have the potential for significant antioxidant activity, with in vitro tests showing possible free radical inhibiting abilities and in vivo tests showing the potential for increased liver healing response and immune enhancement in rat.

Jurnal Health Sains

The Relationship between Platelet Count and Hematocrit with the Severity of Dengue Hemorrhagic Fever at Lendemoripa Christian Hospital – West Sumba – East Nusa Tenggara

EVALUATION OF THE EFFECT OF ANTIOXIDANT AGENTS OF SHRIMP - SEA JELLYFISH (Catostylus sp) bioactive peptide compounds ON MACROSCOPIC CHANGES IN THE LIVER OF WISTAR RATS (Rattus novergicus)